Researchers at Yale University recently evaluated how the consumption of a diet containing high amounts of fat and carbohydrates can have a physiological effect. . They found that inflammation of the hypothalamus, which is located in the base of the brain, occurred days before a physical change occured. . By observing this phenomenon in animal subjects, researchers discovered that change occurred on a cellular level, . with the physical structure of microglial cells being altered because of changes to their mitochondria. . In turn, this affected neurons in the animal’s brains, which triggered a signal that stimulated the animals to eat even more. . Researchers believe that this discovery illustrates how an unhealthy diet can neurologically alter our need to intake food. . There are specific brain mechanisms that get activated when we expose ourselves to specific type of foods. This is a mechanism that may be important from an evolutionary point of view. However, when food rich in fat and carbs is constantly available it is detrimental, Sabrina Diana, Lead Researcher, via Neuroscience News.